5 Reasons Your Joint Pain Keeps Getting Worse After Age 40 - And The Fastest Way To Fix It

A doctor in a white lab coat is seated at a desk, viewed from behind, looking at a computer monitor displaying MRI images of a knee. A skeletal model of a knee joint sits on the desk next to a stack of papers and a mouse.

In This Article, You'll Discover:

How NSAIDs and other painkillers actually shrink the cartilage - and the hidden "joint decay cycle" nobody is testing for

What celebrities are quietly paying $1,800 a session for - and the 7-second-trick that anyone can use

How I helped my wife go from barely walking to going on the trip to Italy she almost gave up on

After 30 years in orthopedic medicine, I've treated over 4,000 patients with joint pain. I kept seeing the same thing — good people doing everything right, still getting worse every year.

Have you ever experienced any of these symptoms?

Morning stiffness that takes 20 minutes just to loosen up

Pain climbing stairs or pushing yourself out of a chair

Nighttime aching that wakes you up and won't let you fall back asleep

My wife had every single one of these symptoms. She's the reason I finally figured out what was behind all of it.

I woke up one night to her sobbing at the bottom of the stairs. She'd tried to come down for a glass of water and her knees gave out halfway down. She was just sitting there on the steps, afraid to move. "I can't do this anymore," she whispered. "I can't live like this."

Couldn't walk more than 3 minutes without stabbing pain. Couldn't stand in the shower long enough to wash her hair. Couldn't get off the couch without pushing herself up with both arms. Three years before, this was the most active woman I knew.

30 years of fixing joints and I could do nothing for her but watch.

Her doctors told her it was normal for her age. Gave her anti-inflammatories. Told her to slow down. She did everything they said. She got worse.

That's when I stopped accepting the standard answers and started looking at what we were all missing. What I found traces every one of those symptoms back to what I now call the joint decay cycle — and nobody is testing for it.

Here are 5 reasons your joint pain keeps getting worse after 50.

1. Your Cartilage Is Breaking Down Faster Than Your Body Can Rebuild It

You know that moment in the morning. You're sitting on the edge of the bed, and before you stand up, you test it. You shift your weight. You grip the mattress. You already know which knee is going to protest.

Your cartilage breaks down a little every day. That's normal. Your body uses collagen — the protein that keeps your joints cushioned and smooth — to rebuild it. For decades, this process kept up just fine.

After 50, your body can't produce enough new collagen to keep up. You lose a little more than you can replace. Every year. The cartilage thins. The surface roughens. Bone starts pressing where it shouldn't.

This isn't your joints breaking down from use. This is your body failing to rebuild what it loses. Nobody is looking at this. They see pain on the X-ray and hand you a pill.

2. Your Repair Cells Are Running on Half Power

Seeded into review by migration

So why did the rebuilding stop? Your cells run on a molecule called NAD — think of it like a rechargeable battery that powers every repair job in your body. Producing collagen, calming inflammation, clearing out damage. After 50, your NAD levels drop by roughly half.

That's why nothing makes sense. You're not doing anything differently. Not running marathons. Not working construction. But every year, the pain gets a little worse. Your repair cells are still showing up to work — they just run out of energy halfway through the job.

Without NAD, your cells can't produce collagen. And even if you supplement it, they don't have the energy to use it for repairs.

The cartilage doesn't get finished. The inflammation doesn't get cleared. And every year, the gap between what breaks down and what gets rebuilt grows a little wider. And what does the medical system do about it?

3. The Pills You Were Told to Take Are Making It Worse

Seeded into review by migration

My wife's doctor put her on prescription NSAIDs. Stronger than what you get over the counter. Pain is inflammation — take an anti-inflammatory. Makes sense.

Her stomach started hurting. She got acid reflux. Started feeling nauseous after meals. And her joints? Still aching. The pills masked the pain for a few hours — but every month, she moved a little less.

What nobody told her is that NSAIDs don't just reduce inflammation — they suppress your body's repair signals. The thing her doctor told her to take every morning was blocking her body's attempt to heal itself.

If nothing has worked so far, it's not because your joints are too far gone. It's because every solution you've tried has been working on the wrong problem.

And that's not even the worst part.

4. Zombie Cells Are Attacking Your Joints From the Inside

As you age, some of your cells stop working — but they refuse to die. Scientists call them senescent cells. The common name is zombie cells.

These zombie cells don't just stop working — they turn against you. They release chemicals that keep your joints swollen, block healthy cells from doing repair work, and spread the damage to the tissue around them.

That's why the exercises didn't work. The diet changes. The physical therapy. None of those things can reach what's happening at this level. Your knees are still worse this year than last year — and now you know why.

Your body is supposed to clear them out. But that takes cellular energy — the same NAD that's been dropping since you turned 50. So the zombie cells stay. And like termites behind drywall, they keep eating through the structure while everything looks fine from the outside.

5. Your Inflammation Won't Shut Off

The science behind every treatment you've been given is right. Anti-inflammatories reduce inflammation. Exercise builds strength. Rest lets the body heal. But they all missed one thing.

The damage never fully stops. Those zombie cells keep releasing chemicals that break down the collagen in your joints. That damage creates new zombie cells. The new ones do the same thing. It's a loop that feeds itself — and nothing you've been given addresses the loop itself.

And here's the part that makes it so hard to fix on your own: the more pain you have, the less active you are. The less active you are, the faster your NAD levels drop. The cycle accelerates itself.

I watched it happen to my wife in real time. Every month she moved a little less. Every month the pain got a little worse. By the time she stopped leaving the house, I knew this wasn't something that was going to fix itself.

Every treatment you've been given targets one piece of this loop. None of them address why the loop exists in the first place.

So What's the Real Solution?

Here's the simple version. Your body isn't broken. It's out of power. I call it the joint decay cycle — and nobody is testing for it.

You've probably tried glucosamine. Collagen. Turmeric. They give your body the raw materials — but without NAD, your cells can't do anything with them. Like a car with a full tank and a dead battery.

The answer had been hiding in plain sight for almost a century.

The Nobel Prize Discovery That Puts WD-40 In Your Joints

I read everything I could find. Medical journals, research papers going back decades. Half the studies were funded by the same companies selling the treatments. Six months. Every night after clinic, I was back at my desk reading studies until my wife came down and told me to go to bed.

Doctor at desk late at night reading medical research papers

What I found made me angry.

In 1931, a scientist named Otto Warburg won the Nobel Prize for mapping the process your body uses to regenerate tissue, fight swelling, and rebuild cartilage. Why joints hold up in your 30s and fall apart by 60. Documented a century ago.

The molecule at the center of all of it? NAD.

After 50, your NAD drops by roughly half. You feel it before you understand it. Mornings that take twice as long. The knee that was fine two years ago and now stops you on the stairs.

So why isn't every doctor in the country testing for it? Because there's no money in it. The system gets paid when you keep coming back — for the shots, the scans, the replacements. Not when you stop needing to.

What Celebrities Were Quietly Paying For While Everyone Else Got Cortisone Shots

So I went looking for a way to restore her NAD — to give her joints the power to repair themselves again. It's not rare — it's in milk, it's in the food on your table. The problem is the amount. To get enough to repair a joint, you'd need about 87 gallons of milk. Per day. Somewhere, someone had to have figured out how to get enough of this into a person's body. I just had to find them.

That's how I found the clinics. Quiet places in LA and Miami. No advertising. Celebrities had been paying for NAD infusions for years and keeping it to themselves. Thirty years in medicine and I'd never heard of them.

ELLE article: What's The Deal With NAD IV Therapy? The Treatment Loved By Kendall Jenner & Hailey Bieber

I got her into one.

After the third session, she came back from a walk around the block. She hadn't done that in over a year. "It's like someone put WD-40 in my knees," she said.

$1,800 a session. We paid it. What else do you do when something actually works?

But we couldn't keep doing that. And when she had to stop, the stiffness crept back in. Then the pain. All of it, right back where it started.

NAD worked. I'd seen it with my own eyes. But at $1,800 a session, it wasn't a real answer. Not for us. Not for anyone who wasn't wealthy.

What I Found When I Went Back to the Research

PubMed study: Characterization of Pharmacologic NAD+ Boosting as a Promising Therapeutic Approach

I couldn't let her go back to where she was. She'd been herself again on that IV. Walking without bracing. Laughing. When the sessions stopped, I watched all the progress vanish. Not long after, the pain came right back.

I kept thinking about that IV. Something in it had turned her joints back on. If I could figure out what, maybe she wouldn't need the clinic at all.

Every night after clinic, I was at my desk. She'd come down and tell me to go to bed and I'd be back at it before she woke up.

It took me months to put it together. Three different ingredients I kept finding in study after study. Each one solved a piece of it. But only when I combined them did everything she'd lost start coming back.

The first was something called Nicotinamide Riboside. I'd passed over it a dozen times before I understood what it actually was. It's in the same family as vitamin B3. But unlike the B3 in your multivitamin, your body converts this one straight to NAD.

Nicotinamide Riboside molecular structure surrounded by NR-rich foods including salmon, mushrooms, milk, and avocado

Feed it directly to your joints and it converts almost entirely to NAD. A 2016 University of Iowa study confirmed it. People who took it saw their NAD levels rise within days. Her joints knew how to rebuild cartilage. They'd just run out of the one thing they needed to do it.

While her NAD levels were dropping, those zombie cells had been piling up in her joints for years. It was crowding out healthy tissue, keeping her joints swollen all the time.

Your body is supposed to clear them. That's what happens in a younger, well-fueled joint. Here, they'd been sitting untouched for years, doing damage the whole time. And those zombie cells don't just sit there. They turn the healthy tissue around them into more zombie cells. Healthy cartilage next to them starts breaking down the same way.

Quercetin molecular structure surrounded by quercetin-rich foods including red onion, capers, broccoli, and cranberries

The Mayo Clinic ran a trial on this. 500mg of quercetin daily for 8 weeks. Morning stiffness dropped. Pain dropped. Not because it masked anything. Because it helped her body clear what had been attacking the joint tissue.

For thirty years I wrote prescriptions for anti-inflammatories. Strong ones. The idea is sound. Pain comes from inflammation, reduce inflammation, reduce pain. And it works. For a few hours.

What no one mentioned in four years of medical school is that NSAIDs don't just reduce inflammation. They stop your joints from rebuilding. You trade a few hours of relief for the one thing that was actually fixing the damage.

Resveratrol molecular structure surrounded by resveratrol-rich foods including red grapes, blueberries, dark chocolate, and pomegranate

Resveratrol is what those pills were SUPPOSED to do. It shuts down the enzymes that grind through cartilage from the inside while keeping the repair signals running. And when you take it with quercetin, the healing doesn't stop after a few hours like it does with NSAIDs. It keeps going.

In a 2012 Cleveland Clinic trial, patients started feeling relief within days. At 90 days the results were still improving. Without destroying your stomach to do it.

I should have figured this out years ago. My patients took everything I prescribed. Exactly as directed. Came back three months later, no better. I thought the supplements didn't work. They work fine. They just never get past your stomach acid.

Your stomach acid destroys most supplements before they ever reach your joints. This has been published research for decades. The companies know. They sell them anyway. Because a bottle that doesn't work is a bottle you replace next month. You start thinking nothing works for you. That your joints are past the point of helping, but they're not. What you were taking never got past your stomach.

Introducing Vasozi NAD+

Vasozi NAD+ daily capsules

I had the three ingredients. I had the research. Everything I'd been reading pointed to the same formula.

Then I found out what happens to most supplements before they ever reach your joints.

Your body is built to extract nutrients from food. That process works fine. The problem is when you skip the food and hand your stomach a concentrated ingredient. It gets destroyed the same way everything else does.

The research on resveratrol showed less than 1% of a standard capsule survives digestion intact. Quercetin was similar. I'd spent months building a formula that was, for practical purposes, destroyed before it could do anything.

CNN Health article: Are vitamins and supplements effectively absorbed?

My first thought was to increase the dose. If 99% gets destroyed, give the body more to work with. I tried every capsule type I could find. Coated ones, time-release ones. A little better each time. Still nowhere close.

I kept searching. There had to be a delivery method that could actually get these ingredients through.

I'd been reading about something called liposomal delivery for weeks. The theory was there. I just couldn't find anyone who'd actually cracked it.

I started asking around. Colleagues I'd worked with over the years. Researchers I trusted. One of them told me about a group of researchers at a small startup called Vasozi. They'd been trying to figure out how to get supplements past stomach acid without losing them.

They'd copied the way your body naturally protects nutrients during digestion. A thin coating around each ingredient that stomach acid can't break down. It passes through intact and releases where your body needs it most.

Dozens of companies had tried to crack this. As far as I could tell, this was the only group that actually had.

I expected maybe two times better absorption. Maybe three.

I ran the numbers. Eight times.

I ran them again. Same number.

The more time I spent with their team, the more I realized how good they were at what they were doing. Then they showed me something I wasn't expecting.

Damaged joint tissue is essentially hungry tissue. It's been broken down and starved of repair signals for years. When the liposomal coating arrives intact, that damaged tissue pulls it in faster than healthy tissue would. The worse your joints are, the more they absorb.

It took six months. Sourcing the highest quality ingredients we could find, from wherever in the world they came from. My dosing. Their delivery system. When the first patients started seeing results neither of us expected, we knew we couldn't keep this to ourselves.

I went back through the research to make sure I wasn't seeing what I wanted to see. 16 clinical studies. More than 90,000 people. What used to cost $1,800 per session at a private clinic? A capsule.

Eight-panel grid of real customers holding the Vasozi NAD+ bottle
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My Wife Was the First Person I Gave It To

Woman smiling on a cobblestone street in Italy, standing in front of outdoor cafes and warm stone buildings

She knew what I'd been working on. She started taking it the day I brought the first bottle home.

She'd been waking up at 2 or 3 every morning for as long as I could remember. She'd shift around for an hour trying to find a position that didn't hurt. Most nights it woke me up too. About a week in, I woke up and it was morning. She was still asleep.

After a few days I said something. 'You've been sleeping better.' She looked at me. 'I know,' she said. 'I didn't want to say anything in case it stopped.'

She'd been using a shower stool for eight months because her knees would lock up if she stood too long. A few weeks in, she stopped needing it.

For a long time she'd planned every outing around whether her knees could handle it. Which parking lot had the shortest walk. Whether it was even worth going. A couple months in, now she was just going.

We had friends in Italy who'd been asking us to come for years. Walking tours. Cobblestone streets. Every time it came up she'd say maybe next year. I'd stopped bringing it up. One night she just said, 'Let's do Italy.' We booked it that week.

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Then I Started Giving It to Patients

I started giving it to patients I'd been treating for years. Mostly joint pain. The same thing kept happening. Some noticed sleep first. Others felt it in their knees within two weeks. One patient stopped scheduling his cortisone shots. He'd been getting them twice a year.

Hand holding a bottle of Vasozi NAD+ outdoors in a sunny backyard with a pool in the background

A lot of them came back and told me things I didn't expect. They had more energy. They weren't getting sick as much. A few mentioned their memory. They came in for joint pain, but the ingredients in the formula don't just work on joints. They work on the systems the decay cycle was breaking down.

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Second eight-panel grid of real customers holding the Vasozi NAD+ bottle

Real Results From Real People

As of now, thousands of people nationwide are using Vasozi NAD+ to ease their joint pain and reclaim their active lifestyle. Our products have thousands of 5-star reviews from people who have gotten their lives back. 4672 Ratings

Robert M.
Robert M.

It's been a few weeks now, and I'm absolutely sold. Does it erase 30 years of damage? No. But I can MOVE again. I'm doing things I'd given up on because the pain was so bad. Simple stuff like housework or even light hiking. Things I used to skip because of constant back tension.

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Rita Carroll
Rita Carroll

When you get older, your joints start talking to you. It's great that supplements like this actually help. When I forget to take it, I definitely feel it. This helps with the stiffness and achiness I often feel without it.

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Tom Granger
Tom Granger

I was skeptical. Tried glucosamine, turmeric, fish oil. Nothing moved the needle. My wife talked me into trying this. Six weeks in, I'm back in the garden. No pain the next day. Didn't expect that.

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What Is a Pain-Free Life Worth to You?

Patients started buying extra bottles for their parents. Their siblings. People I'd never met were emailing me to say it was working. Over 94,510 people are taking it now, and the pattern is always the same. Sleep first. Then the joints. Then the rest.

Bioavailability comparison chart showing liposomal Vasozi at 71% absorption versus 22% for regular capsules and 39% for powder

I'll be honest. Vasozi NAD+ isn't the cheapest joint supplement on the market. And I don't hide from that at all. Quality costs money and everyone knows that. You buy a cheap pair of shoes and you expect them to wear out quickly. They're also not the shoes you're going to wear to a nice dinner with your husband or your wife. Vasozi wasn't made to be priced to sell. It was made to be effective. And yet it sells incredibly well. We've even had to take it off the market a few times because we were waiting for more inventory to come in.

That also doesn't mean it's an expensive supplement. I want to give you back the freedom that the pain has stolen from you, but I don't want price to be the reason you say no.

Here's What to Do Next

Five bottles of Vasozi NAD+ arranged on a kitchen counter

So here's what we're doing today. Every new customer gets the chance to try one bottle of Vasozi NAD+ for just $39.99. That's half off what it normally costs. You get one bottle at a fair price, you try it, and I'm willing to bet it works so well you're going to want more. Except when you come back for more, you'll actually pay less. Buy two bottles and we'll send you a third one free. That brings it down to less than $27 a bottle. And if you really want to get ahead of this, buy three and we'll send you five. That's five months for just $24 a bottle.

Price comparison showing $79 original price crossed out and $39 discount price, with the Vasozi NAD+ bottle and a single capsule in hand

Try It Yourself — On My 90-Day Promise

Every order is backed by our 90-day money back guarantee. Try it, use it, and if you don't start feeling the difference in your knees, your back, your shoulders, your hips, if the stiffness doesn't start to fade, if the soreness doesn't begin to ease up, if you don't start moving more freely, just send it back. Even if the bottle is empty, we will give you every penny back. No questions, no hoops, no problem.

90-day money back guarantee seal with personal guarantee note from Dr. Whitfield

You're Standing at a Fork in the Road

I've seen it too many times to count. And I'll tell you what I tell every patient who sits across from me.

Right now, you're standing at a fork in the road.

One path leads to more of the same. More stiffness. More hesitating at the top of the stairs. More avoiding walks. More conversations with your partner about the possibility of surgery.

A man standing at a fork in the road choosing between two paths — one leading to decline, the other to an active life

And the other path, that one leads to relief. To stepping out of bed without wincing. To bending down without grunting and groaning. To walking with confidence and not fear. And to feeling like yourself again.

Vasozi NAD+ is your chance to take that other path. And you don't have to wait months to feel it.

Most of my patients begin to notice a difference in just seven to 10 days. The stiffness softens. The swelling calms down. And that tension in your joints, the kind you forgot wasn't normal, it starts to disappear.

A single bottle is a perfectly fine way to start. But the one thing my patients keep telling me is that it works better the longer they take it. That's why the three and five-bottle options make the most sense, and why we price them the lowest we can.

So go ahead. Click the link below, choose the option that's right for you, and ask yourself what life would look like if stiff, sore joints just weren't a part of it anymore.

Start My 90-Day Trial

Free shipping • 90-day money-back guarantee

Scarcity graphic showing Amazon and eBay logos crossed out, with the Vasozi NAD+ bottle marked with a checkmark

Take the First Step Today

Think about it:

- Joint replacement surgery costs $20,000 or more - Physical therapy sessions can be painful and time consuming - Pain medications add up to hundreds yearly and only mask symptoms - Missing out on life with family? That cost is impossible to measure

NOTE: This deal is NOT available on Amazon or eBay.

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Wilma Dela Cruz
Wilma Dela CruzCan anybody vouch for this? Seems too good to be true.
·Reply·51 min
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Mary Vermont
Mary Vermont@Wilma Hey Wilma, it's legit! I used to wake up stiff and sore every single morning. Started taking it about two months ago and the difference is night and day. I can get through my whole morning routine without stopping to sit down.Photo attached by Mary Vermont
·Reply·16 min
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Leonard Boyd
Leonard BoydI bought these for my wife. She's 62 and was dealing with constant knee pain for over a year. About three weeks in, she started walking to the mailbox again without her cane. Haven't seen that in months.Photo attached by Leonard Boyd
·Reply·6h
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Doris Steiner
Doris SteinerI bought mine at full price, and now they're 50% off? That's not fair!
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Skyler Greig
Skyler GreigHow long does shipping take??
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Marie Campbell
Marie Campbell@Skyler Hey Skyler, got mine after a week.
·Reply·24 min
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Emma Emerson
Emma EmersonFinally something that actually works. On my third bottle.
·Reply·8h
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Louis Clive
Louis CliveJust ordered mine. Cannot wait to try it!
·Reply·11h
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Barbara Bradly
Barbara BradlyI was VERY skeptical. Wasted money on glucosamine for two years. My daughter convinced me to try this instead. Four weeks later and my morning stiffness is half what it was. I can actually make breakfast without holding onto the counter.Photo attached by Barbara Bradly
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Alfred Johnson
Alfred JohnsonDoes anyone know if they ship internationally?
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Editha Cruz
Editha Cruz@Alfred For me, it was about 3 business days. Super fast.
·Reply·2h
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Debra Peyton
Debra PeytonFive weeks in. I take it every morning with my coffee. The biggest change for me is stairs. I used to grip the railing and go one step at a time. Now I just walk up like a normal person. Sounds small but it means everything.
·Reply·18h
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Paula Remington
Paula RemingtonHas anyone actually had their blood work done before and after? Curious if it shows up.
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Sarah Dudley
Sarah DudleyBack to gardening on weekends. Couldn't kneel down for over a year. Now I'm out there pulling weeds like I'm 40 again.
·Reply·2h
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Chris Graeme
Chris GraemeJust ordered! Fingers crossed.
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Howard Prescott
Howard PrescottMy wife and I both take it now. She noticed the difference before I did honestly. Said her hands stopped aching in the mornings after about 3 weeks.
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Anna Madison
Anna MadisonStarted this about six weeks ago after my physical therapist mentioned NAD. The swelling in my knees has gone down noticeably and I'm sleeping through the night again. Haven't been able to say that in two years.
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Eddie Orson
Eddie OrsonTwo months in and I'm back on the golf course twice a week. Hadn't swung a club in over a year because of my shoulder and hip.
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Ethel Dean
Ethel DeanDoes anyone know how long the shipping takes? Want to buy some for my friend.
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Clark Milton
Clark Milton@Ethel Hey Ethel, mine arrived after about a week.
·Reply·6h
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